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Symptoms vary greatly from case to case depending upon the exact size and location of the deleted genetic material.Common symptoms include a distinctive cry that resembles the mewing of a cat, characteristic facial features, slow growth, and microcephaly, a condition that indicates that head circumference is smaller than would be expected for an infant's age and sex.Prematurely graying of the hair has also been reported.

Introduction The disorder was first described in the medical literature in 1963 by doctor Lejeune who named the disorder after the distinctive cat-like cry.About half of children with cri du chat syndrome were able to dress themselves by age 5 years.Moderate to severe intellectual disability is present in most cases.Most affected infants also display some degree of psychomotor and intellectual disability.Psychomotor disability is a delay in the acquisition of skills requiring mental and muscular activities such head control, sitting up, and walking.Approximately 15-20 percent of affected infants have congenital heart defects.

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